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Zachary Z. Freyberg M.D, Ph.D.

  • Associate Professor
Research Interests

Activity-dependent local translation in Alzheimers; Dopamine neuron vulnerability; aging & Parkinson's; Antipsychotic drug-induced metabolic syndrome

Representative Publications
  1. Buck SA, Steinkellner T, Aslanoglou D, Villeneuve M, Bhatte SH, Childers VC, Rubin SA, De Miranda BR, OLeary EI, Neureiter EG, Fogle KJ, Palladino MJ, Logan RW, Glausier JR, Fish KN, Lewis DA, Greenamyre JT, McCabe BD, Cheetham CEJ, Hnasko TS, Freyberg Z. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration. Aging Cell 2021; 20(5):e13365. doi: 10.1111/acel.13365. PubMed PMID: 33909313.
  2. Aslanoglou D, Bertera S, Sanchez-Soto M, Free RB, Lee J, Zong W, Xue X, Shrestha S, Brissova M, Logan RW, Wollheim C, Trucco M, Yechoor V, Sibley D, Bottino R, Freyberg Z. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Translational Psychiatry 2021; 11(1):59. doi:10.1038/s41398-020-01171-z. PubMed PMID: 33589583.
  3. Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Li W, Calderon MJ, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z. Ribosome-Associated Vesicles: a dynamic vesicular endoplasmic reticulum in secretory cells. Science Advances 2020; 6(14):eaay9572. doi: 10.1126/sciadv.aay9572. PubMed PMID: 32270040.
  4. Aguilar JI, Dunn M, Mingote S, Karam CS, Farino ZJ, Sonders MS, Choi SJ, Grygoruk A, Zhang Y, Cela C, Choi BJ, Flores J, Freyberg RJ, McCabe BD, Mosharov EV, Krantz DE, Javitch JA, Sulzer D, Sames D, Rayport S, Freyberg Z. Neuronal depolarization drives increased dopamine synaptic vesicle loading via VGLUT. Neuron 2017; 95(5):1074-1088. doi: 10.1016/j.neuron.2017.07.038. PubMed PMID: 28823729.